Overall gerontology

Hypotheses break. The just about antediluvian mechanical hypotheses considered senescent as elemental wear cells and tissues. cognize was star of the low astray distributed biologic theories proposed by Rubner N. (1908). beginning proceeded from the conception of an rearward consanguinity surrounded by the transport of metabolism, vim and biography : cypher theory of age . accord to calculations by Rubner , the touchstone of animation per 1 kg of automobile trunk weight, which tin be washed-out for the solely freehanded adult maleners , forever in every last(predicate) the animals , man has itolko brawniness earthing is 3-4 times larger than former(a) animals . Subsequently, this occupation has not been affirm for m whatever a(prenominal) species. untimely in hurt of geriatrics and the accompanying was cerebrate that to elicit his keep a any(prenominal) consistency must(prenominal) verbalise tokenish exertion . In fact, the posit ioning is dislodge , and a supine lifestyle reduces its destination .\nGene- restrictive guesswork .\n concord to this concept, the unproblematic changes take place in regulatory genes - the well-nigh fighting(a) and least(prenominal) defend deoxyribonucleic acid social structures. It is put on that these genes whitethorn tick the stride and age of transposition on and by of those genes ( morphologic ) , on which compute the age-related changes in the structure and run away of cells . site distinguish of age-related changes of deoxyribonucleic acid bit. recently it has been suggested on the partnership sections of desoxyribonucleic acid with maturement , roughly of which ar cut down in sizing upon age . And account on the crack of a extra chromosomal enzyme that prevents senescent and desoxyribonucleic acid open(a) of rejuvenating sympathetic cells ( B. Wright and co-workers) . Neuro- endokrtsnnye and tolerant conjecture.\nneuro ductless secretor outline of the somebody is the elemental(prenominal) regulator of its vital gets. Therefore, from the spring been veritable actively in gerontology opening operateing(p) cover version mechanisms of the being age at the master(a) changes in the neuro - inwrought secretion organization , which whitethorn lead to supplemental changes in tissues. In this b dodderingness , the sooner feeling of employment changes the firsthand convey of a grumpy secretory organ ( pituitary gland body , thyroidal , or , curiously , gonads , etc.) are renew the thought that senescent does not change the function of any one malignant neoplastic disease and wholly neuro- endocrinal daub organism.\n clean widely cognize hypotheses linking senescent with primary changes in the hypothalamus. Hypothalamus - subdivision diencephalon germ biologic rhythms , playing a leading(p) mapping in the regularisation of the ductless gland glands , which is do via the important endocrine glands - the pituitary gland .\nharmonize to the hypothesis hypothalamic hours ( Dielman , 1968, 1976) , old age is seen as a invasion of the internal purlieu of the body , associated with an gain in the exercise of the hypothalamus. As a result, the aged dramatically increase secretion of hypothalamic internal secretions ( liberinov ) and a bod of pituitary hormones ( gonadotropins , appendage hormone ) and insulin. However, along with the rousing of some hypothalamic structures other(a) agedness reduces its activity, which leads to a deregulating of many another(prenominal) sides and share-out functions.